article
Research Articles
 
 

Applying microstructural models to understand the role of white matter in cognitive development

Huber, E., Henriques, R. N., Owen, J. P., Rokem, A., & Yeatman, J. D. (2019). Applying microstructural models to understand the role of white matter in cognitive
development. Developmental Cognitive Neuroscience, 36, 100624. Retrieved from
https://doi.org/10.1016/j.dcn.2019.100624

Abstract

Diffusion MRI (dMRI) holds great promise for illuminating the biological changes that underpin cognitive development. The diffusion of water molecules probes the cellular structure of brain tissue, and biophysical modeling of the diffusion signal can be used to make inferences about specific tissue properties that vary over development or predict cognitive performance. However, applying these models to study development requires that the parameters can be reliably estimated given the constraints of data collection with children. Here we collect repeated scans using a typical multi-shell diffusion MRI protocol in a group of children (ages 7–12) and use two popular modeling techniques to examine individual differences in white matter structure. We first assess scan-rescan reliability of model parameters and show that axon water faction can be reliably estimated from a relatively fast acquisition, without applying spatial smoothing or de-noising. We then investigate developmental changes in the white matter, and individual differences that correlate with reading skill. Specifically, we test the hypothesis that previously reported correlations between reading skill and diffusion anisotropy in the corpus callosum reflect increased axon water fraction in poor readers. Both models support this interpretation, highlighting the utility of these approaches for testing specific hypotheses about cognitive development.

view more
Connect with us
Lindamood-Bell Academy provides personalized learning that is tailored to each student’s needs. Enroll now for special savings.
➢ 25% off a month of tuition
➢ $500 off Summer Learning in reading, comprehension, or math.
Get details at the link in our bio, @lindamoodbellofficial.
.
.
.
#lindamoodbellacademy #privateschool #personalizedlearning #customizedlearning #lindamoodbell
This summer, you can count on Lindamood-Bell to help your child stay on track and reach their amazing potential. Our fun and effective instruction is evidence-based and tailored to each student's needs. Your child can return to school with stronger academic skills and new confidence. Enroll now for special savings on the first week of instruction! Hurry, summer spots are filling fast! ⏳
Follow the link in our bio, @lindamoodbellofficial.
Lindamood-Bell summer instruction helps students catch up or get ahead in Reading, Comprehension, and Math—in a matter of weeks. Visit our website to learn about a summer program for your child. Follow the link in our bio, @lindamoodbellofficial.
Hurry, summer spots are filling fast! ⏳

.
.
.
#lindamoodbell #dyslexia #dyslexic #testimonial #summercamp
Join us this summer—our learning centers are hiring now!
We’re seeking energetic, positive individuals who want to make a difference for students. The Clinician(Tutor) role includes paid training in our evidence-based approach. View our open positions and get started! Link in our bio, @lindamoodbellofficial.
.
.
#lindamoodbell #nowhiring #hiring #summerjob
Lindamood-Bell Academy provides personalized learning that is tailored to each student's needs. Enroll now for special offers.
➢ 25% off a month of tuition
➢ $500 off Summer Learning in reading, comprehension, or math.
Get details at the link in our bio, @lindamoodbellofficial.
Lindamood-Bell Academy is a school designed for your child! Our individualized school curriculum and evidence-based instruction are tailored to your student’s needs. Enroll now for 2023-24 and receive 25% off a month of tuition!
Follow the link in our bio, @lindamoodbellofficial.
.
.
.
#LindamoodBellAcademy #LindamoodBell #EnrollingNow #privateschool #PersonalizedLearning #Dyslexia #ADHD
New Podcast Episode!
Lindamood-Bell’s Director of Research & Development, Paul Worthington, shares valuable insights into common dyslexia misconceptions, peer-reviewed interventions, and the latest research. Listen and subscribe at the link in our bio, @lindamoodbellofficial
.
.
.
#lindamoodbell #dyslexia #scienceofreading
June is National Pride Month. Join us in celebrating the contributions LGTBQ+ Americans have made to the nation's culture, history, and collective knowledge. The Smithsonian commemorates National Pride Month with events, resources, and podcast episodes that tell diverse Pride stories. Follow the link in our bio to visit their website!
Imagine your child going back to school with better skills and new confidence!💪
Lindamood-Bell summer learning helps students catch up or get ahead in Reading, Comprehension, and Math—in a matter of weeks! ☀️📚
Find your local learning center at the link in our bio, @lindamoodbellofficial.
Hurry, summer spots are filling fast! ⏳

.
.
.
#lindamoodbell #dyslexia #dyslexic #testimonial #summercamp
Looking for a summer job where you can make a difference and gain valuable experience? Our learning centers are hiring now! The Clinician (Tutor) role includes paid training in our evidence-based approach. View our open positions and apply today. Follow the link in our bio, @lindamoodbellofficial.
.
.
.
#lindamoodbell #nowhiring #hiring #summerjob
At Lindamood-Bell, we believe that all individuals can be taught to read to their potential—including those previously diagnosed with a learning difficulty such as dyslexia. Visit our website to learn more about common dyslexia misconceptions, the latest research, and how Lindamood-Bell summer instruction can help your child. Follow the link in our bio, @lindamoodbellofficial.
Our free webinar is now available on demand. Lindamood-Bell's Director of Research and Development, Paul Worthington, shares valuable insights into common dyslexia misconceptions, peer-reviewed interventions, and the latest research. Watch now at the link in our bio, @lindamoodbellofficial.
New Podcast Episode!
Lindamood-Bell for Schools Director of Development, Dave Kiyvyra, is joined by Heidi O’Leary, the Director of Special Education for Maine School Administrative District 75. They discuss how the district successfully implemented evidence-based literacy instruction. Listen and subscribe at the link in our bio, @lindamoodbellofficial
.
.
.
#lindamoodbell #specialeducation #scienceoflearning #dyslexia #teachersofinstagram #scienceofreading
Lindamood-Bell Academy provides individualized school curriculum and evidence-based instruction. The Academy can be an ideal setting for students previously diagnosed with dyslexia, ADHD, and other learning challenges. 
Now enrolling for the 2023-24 school year! Follow the link in our bio, @lindamoodbellofficial.
.
.
.
#LindamoodBellAcademy #LindamoodBell #EnrollingNow #privateschool #PersonalizedLearning #Dyslexia #ADHD
Request Information
Menu
Loading ...

Request Information

When you complete our form, we'll send you to our digital information packet and reach out to you shortly.
You may also call us at

Choose at least one option. *
* required

Schedule a Learning
Ability Evaluation

Please fill out the form and we will be in touch to schedule an evaluation.

* required
Chat with a Live Representative